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Charles Darwin, Missing Teeth, and Molecular Biology

December 31st, 2014

CHARLES DARWIN FIRST DOCUMENTED the incidence of missing teeth:

..in a Hindu family in Scinde...ten men, in the course of four generations, were furnished, in both jaws with only four small and weak incisor teeth and eight posterior molars.

Father’s X-Ray

Tooth Agenesis May Be More Common Than You Think

The incidence of tooth agenesis “lack of development” of teeth ranges from 1.6% to 9.6% in the general population excluding third molars. The term “congenitally” missing teeth, commonly used in dentistry, is a misnomer since permanent teeth are not normally present in the mouth at birth.

Maxillary laterals incisors have been noted to be the most frequently missing teeth when only one or two teeth are absent. The Dariusleut Hutterites of western Canada have the highest incidence of maxillary lateral tooth agenesis found in 47% of this population.

Tooth Agenesis Can Increase Through Generations

Tooth agenesis is a familial trait. Hypodontia, small number and size of teeth, is determined by a dominant autosomal gene pattern with incomplete penetrance and variable expressivity. Children inherit tooth agenesis from less severely affected parents. Tooth agenesis increases in number and magnitude after the mating of affected subjects.

Son’s X-Ray

Hypodontia May Be Linked To Ectodermal Dysplasia

Several authors have suggested that hypodontia is “micro” form of ectodermal dysplasia. Besides aberrations in the permanent dentition, these patients also exhibit delayed tooth eruption, hair and nail dysgenesis, dry skin, bilateral congenital hip dislocation and an asthmatic condition.

Several genes have been found to be required for the development or teeth. In the most specific human molecular study Vastaridis, H. (1996) found that a point mutation of a G to C transversion in the MSX1 gene at nucleotide residue 2125 produces tooth agenesis.

The G to C transversion results in the substitution of a positively-charged arginine to a neutral proline at residue 31 of the MSX1 homeodomain. Arg31 is within helix II of the homeodomain located close to the backbone of the alpha strand of DNA, and is thought to specifically interact with DNA via a salt bridge to the G-5 phosphate group. Perhaps the ARG31Pro mutation similarly attenuates MSX1 interaction with target DNA.

Orthodontists Can Recognize And Treat This Condition

Orthodontist Ann Marie Gorczyca, DMD, MPH, MS spent four years in the UCSF Oral Biology PhD program. She is a member of the Angle Society of Orthodontists where she presented the paper: “Tooth Agenesis: A Molecular Genetic Model.”

Orthodontists should be encouraged to extensively inquire about the family history of individuals with dental anomalies. Orthodontists could play a crucial role in the diagnosis of underreported entities of ectodermal dysplasia by bringing attention to its oral manifestations. Patients with numerous missing teeth should be referred to an orthodontist and a dermatologist.

How Does Diabetes Affect Orthodontic Treatment?

December 19th, 2014

347 MILLION PEOPLE WORLDWIDE have diabetes, and that number grows every year. Diabetes affects all areas of people’s health, from the skin to the kidneys. Diabetes can also cause severe dental health issues.

Diabetes Increases Gum Disease Risk

Research has shown that people with diabetes are more likely to develop periodontal disease. Periodontal disease is a serious health problem that can lead to bone and tooth loss if not properly managed.

Periodontitis Can Also Reduce One’s Ability To Control Blood Sugar

Periodontitis (an advanced stage of gum disease) can make blood sugar levels spike and fluctuate. Additional research suggests that when diabetic patients gain control of gum disease, they can also gain better control of their diabetes.

Can Periodontal Disease Affect Orthodontic Treatment?

Many patients with diabetes needs orthodontic treatment. When bone is lost surrounding teeth, often these teeth move into undesirable positions. Bone loss in the presence of inflammation, as found in periodontitis, can result in unpredictable orthodontic tooth movement during orthodontic treatment.

That’s why, at Gorczyca Orthodontics, we send every adult orthodontic patient for a thorough periodontal examination with a periodontist prior to starting active orthodontic therapy.

Periodontist, Dr. Nancy Dubuk of Deer Valley Professionals, 5201 Deer Valley Road in Antioch, California says:

“A diabetic patient seeking orthodontic treatment can be stable with blood sugars under control with proper monitoring. These patients can maintain their periodontal health well, as long as they are on a good oral hygiene maintenance schedule, both at home and professionally. Once these are established, they can begin orthodontic treatment.”

Help Us Raise Awareness About Diabetes-Related Periodontal Disease

What Can You Do To Prevent Periodontal Disease?

Patients can brush and floss twice per day to prevent periodontal disease. Be sure to have professional cleanings done at least twice per year with your dentist. Ask your dentist to complete a thorough periodontal exam, which includes pockets probing measurements and full mouth series radiographs. If bony pockets deeper than 4 mm exist, early treatment by a periodontist can help prevent further bone loss.

For more information about periodontal disease, contact the American Academy of Periodontology at www.perio.org. To find an orthodontist near you, visit the American Association of Orthodontists at www.mylifemysmile.org.

Oral hygiene maintenance and beautifully white straight teeth will help you prevent the danger of of diabetes associated periodontal disease. Let your periodontist and orthodontist help you achieve a beautiful smile.

To learn more about adult orthodontics, call us at Gorczyca Orthodontics (925) 757-9000 or visit us at www.clubbraces.com.

Share This Information With Someone You Know

Most of us know at least one person who is affected by these diseases. If you have a friend, family member, neighbor, or coworker who has diabetes or periodontitis, share this information with them! It’s essential that they understand the relationship between these two things—and, what they can do to help improve their situation.

Thank you for your trust in our practice!

What is the Edward H. Angle Society?

December 16th, 2014

ON NOVEMBER 17, 1930, twenty-two former graduates of Dr. Angle’s School of Orthodontia met in Chicago. The purpose of their meeting was to “find some way to carry forward Dr. Angle’s ideals of orthodontia.” That day, the Edward H. Angle Society of Orthodontists was born.

Angle Society Members Are Characterized By Excellence In The Field

The forty-six charter members of the Angle Society of Orthodontists were giants in the field of orthodontics. Founding members included the late Dr. Angle’s wife, Dr. (Mrs.) Anna Hopkins Angle, Director of the Angle School and herself one of the first women in dentistry and orthodontics, as well as Drs. Brodie, Tweed, Noyes, Broadbent, Hahn, Steiner, and Hellman, all of whose contributions to the field of orthodontics has been legendary.

Today, the Edward H. Angle Society of Orthodontists has over 500 members worldwide. Characteristics of Angle Society members include excellence in orthodontics as well as participation and involvement in dental, orthodontic, academic, and civic organizations.

Membership Is Achieved By Invitation Only

Angle Society membership is achieved by invitation only from your component Board of Director members. Membership requirements include an Oral Case presentation, an orthodontic thesis of independent investigation, and six written case reports for evaluation. The membership process usually takes five years to complete. All of these requirements must meet the standard of excellence in orthodontics set by the Angle Society.

The National Biennial meeting of the Edward H. Angle Society has proven internationally to be one of the most outstanding orthodontic meetings. Programs consist of speakers from various components from across the globe.

Are You Interested In Becoming An Angle Society Member?

If you are interested in becoming an Angle Society member, please contact a member in your local dental community. Dr. Ann Marie Gorczyca is a member in Northern California, and is the first women member of that society, and the only member from East Contra Costa County. For additional questions about the Angle Society, call her at (925) 757-9000.
 
“You will shoot no higher than you aim, so raise your sights a little and never forget that perfection is the ultimate goal. You may never reach it, although the closer you approach it, the greater will be the feeling of contentment in your own soul. A person’s own conscience, after all, is his most formidable critic.”

-Dr. George Hahn
Founding Member, Angle Society of Orthodontists

All I Want For Christmas Are My Two Front Teeth

December 11th, 2014

SOMETIMES UPPER FRONT TEETH don’t come in on time. If more than one year passes since the expected time of arrival of an upper front tooth, usually at age 7, and the front tooth is still delayed, it’s time to take action and visit an orthodontist.

There Are Many Possible Causes...

There are many possible causes of delayed permanent front teeth.

1. A baby tooth may be lost too early due to a cavity or an accident. When this happens, bone and tissue fills the tooth path and the permanent tooth may not be able to push its way out.

2. A baby tooth can be maintained too long. A baby not loose and firmly in place too long may not allow a permanent tooth to come in or may cause the permanent tooth to come in out of place.

3. An extra front tooth in the middle of both front teeth can prevent these front teeth from coming in. This extra middle tooth is called a mesiodens. Sometimes this tooth comes into the roof of the mouth or it may stay stuck in the bone.

4. Front teeth may be deformed, turned sideways, or even upside down. This situation will require a surgical procedure and attachment of a metal chain to pull the tooth into position with braces.

Get An Orthodontic Evaluation By Age 7!

In all of these situations, orthodontic space preparation is important. In some cases, a surgical incision may be all that is necessary to release a front tooth and allow it to come into position.

The esthetic and social consequences of a missing front tooth for a child are significant. This is why the American Association of Orthodontists recommends that every child have an orthodontic evaluation by age 7.

So please bring your child to Gorczyca Orthodontics in Antioch, California for a complimentary consultation if you hear them say "All I want for Christmas are my two front teeth."

More Topics
diplomate american board of orthodontics Edward H. Angle Society of Orthodontists advanced education in orthdontics
member american association of orthodontists seattle study club american dental association california dental association
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